loading...| Preferred Name | Niacin | |
| Synonyms |
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|
| Definitions |
A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C689 |
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| ALT_DEFINITION |
Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases for the transfer of the hydride ion. (DRI) A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some enzymes work properly and helps skin, nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in every day. Not enough niacin can cause a disease called pellagra (a condition marked by skin, nerve, and digestive disorders). A form of niacin is being studied in the prevention of skin and other types of cancer. Niacin may help to lower blood cholesterol. |
|
| CAS_Registry |
59-67-6 |
|
| CHEBI_ID |
CHEBI:15940 |
|
| Chemical_Formula |
C6H5NO2 |
|
| code |
C689 |
|
| Contributing_Source |
CRCH CTRP FDA |
|
| definition |
A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C. |
|
| Display_Name |
Niacin |
|
| FDA_UNII_Code |
2679MF687A |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| INFOODS |
NIA |
|
| label |
Niacin |
|
| Legacy Concept Name |
Niacin |
|
| Micronutrient |
Y |
|
| NCI_Drug_Dictionary_ID |
38351 |
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| NSC Number |
169454 |
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| Nutrient |
Y |
|
| PDQ_Closed_Trial_Search_ID |
38351 |
|
| PDQ_Open_Trial_Search_ID |
38351 |
|
| Preferred_Name |
Niacin |
|
| prefixIRI |
NCIT:C689 |
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| prefLabel |
Niacin |
|
| Semantic_Type |
Organic Chemical Vitamin |
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| Tolerable_Level |
Y |
|
| UMLS_CUI |
C0027996 |
|
| Unit |
mg |
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| US_Recommended_Intake |
Y |
|
| USDA_ID |
406 |
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| subClassOf |