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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C68845
http://purl.obolibrary.org/obo/NCIT_C68845
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|---|---|
| Preferred Name | Abiraterone Acetate |
| Definitions |
An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally active acetate ester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. |
|---|---|
| prefLabel | Abiraterone Acetate
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| label | Abiraterone Acetate
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| PDQ_Closed_Trial_Search_ID | 552704
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| code | C68845
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| Has_Target | |
| prefixIRI | NCIT:C68845
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| in_subset |
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| Display_Name | Abiraterone Acetate
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| Preferred_Name | Abiraterone Acetate
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| FDA_UNII_Code | EM5OCB9YJ6
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C26H33NO2
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| Maps_To | Abiraterone Acetate
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| CAS_Registry | 154229-18-2
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| NCI_Drug_Dictionary_ID | 552704
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| Legacy Concept Name | Abiraterone_Acetate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A substance being studied in the treatment of prostate cancer and breast cancer. It blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of cancer cells that need androgens to grow. It is a type of anti-androgen.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 552704
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| Accepted_Therapeutic_Use_For | Castration-resistant prostate cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2607886
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