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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C68820
http://purl.obolibrary.org/obo/NCIT_C68820
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|---|---|
| Preferred Name | CHK1 Inhibitor PF-477736 |
| Definitions |
A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. |
|---|---|
| prefLabel | CHK1 Inhibitor PF-477736
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| label | CHK1 Inhibitor PF-477736
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| PDQ_Closed_Trial_Search_ID | 539740
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| code | C68820
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| Has_Target | |
| prefixIRI | NCIT:C68820
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| in_subset |
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| Display_Name | CHK1 Inhibitor PF-477736
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| Preferred_Name | CHK1 Inhibitor PF-477736
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| FDA_UNII_Code | XO23PGZ0SM
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| Contributing_Source |
CTRP
FDA
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| Maps_To | CHK1 Inhibitor PF-477736
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| CAS_Registry | 952021-60-2
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| NCI_Drug_Dictionary_ID | 539740
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| Legacy Concept Name | CHK1_Inhibitor_PF-477736
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 539740
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C4049082
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