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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C673
http://purl.obolibrary.org/obo/NCIT_C673
|
|---|---|
| Preferred Name | Mycophenolic Acid |
| Definitions |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04) |
|---|---|
| prefLabel | Mycophenolic Acid
|
| label | Mycophenolic Acid
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:168396
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| PDQ_Closed_Trial_Search_ID | 732227
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| code | C673
|
| prefixIRI | NCIT:C673
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| in_subset |
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| Display_Name | Mycophenolic Acid
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| Preferred_Name | Mycophenolic Acid
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| FDA_UNII_Code | HU9DX48N0T
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C17H20O6
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| Maps_To | Mycophenolic Acid
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| CAS_Registry |
24280-93-1
483-60-3
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| NSC Number | 129185
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| NCI_Drug_Dictionary_ID | 732227
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| Legacy Concept Name | Mycophenolic_Acid
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 732227
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| Accepted_Therapeutic_Use_For | Prophylaxis of organ rejection after allogenic renal; cardiac; or hepatic transplants; psoriasis
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0026933
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