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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C67083
http://purl.obolibrary.org/obo/NCIT_C67083
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|---|---|
| Preferred Name | Oral Sodium Phenylbutyrate |
| Definitions |
An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone deacetylase, resulting in cell cycle gene expression modulation, reduced cell proliferation, increased cell differentiation, and apoptosis. This agent also initiates fragmentation of genomic DNA, resulting in decreased DNA synthesis and the inhibition of tumor cell migration and invasion.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone deacetylase, resulting in cell cycle gene expression modulation, reduced cell proliferation, increased cell differentiation, and apoptosis. This agent also initiates fragmentation of genomic DNA, resulting in decreased DNA synthesis and the inhibition of tumor cell migration and invasion. |
|---|---|
| prefLabel | Oral Sodium Phenylbutyrate
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| label | Oral Sodium Phenylbutyrate
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| PDQ_Closed_Trial_Search_ID | 41827
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| code | C67083
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| Has_Target | |
| prefixIRI | NCIT:C67083
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| in_subset |
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| Display_Name | Oral Sodium Phenylbutyrate
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| Preferred_Name | Oral Sodium Phenylbutyrate
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| Contributing_Source | CTRP
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| Maps_To | Oral Sodium Phenylbutyrate
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| NCI_Drug_Dictionary_ID | 41827
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| Legacy Concept Name | Oral_Sodium_Phenylbutyrate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41827
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1882164
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