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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C67075
http://purl.obolibrary.org/obo/NCIT_C67075
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|---|---|
| Preferred Name | Cell Cycle Checkpoint/DNA Repair Antagonist IC83 |
| Definitions |
A proprietary agent with potential antineoplastic activity. IC83 appears to target cell cycle checkpoint/DNA repair enzymes, which are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Inhibition of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging agents and dissipate tumor cell resistance to chemotherapy and radiation therapy.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A proprietary agent with potential antineoplastic activity. IC83 appears to target cell cycle checkpoint/DNA repair enzymes, which are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Inhibition of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging agents and dissipate tumor cell resistance to chemotherapy and radiation therapy. |
|---|---|
| prefLabel | Cell Cycle Checkpoint/DNA Repair Antagonist IC83
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| label | Cell Cycle Checkpoint/DNA Repair Antagonist IC83
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| PDQ_Closed_Trial_Search_ID | 536220
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| code | C67075
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| prefixIRI | NCIT:C67075
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| in_subset |
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| Display_Name | Cell Cycle Checkpoint/DNA Repair Antagonist IC83
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| Preferred_Name | Cell Cycle Checkpoint/DNA Repair Antagonist IC83
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| Contributing_Source | CTRP
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| Maps_To | Cell Cycle Checkpoint/DNA Repair Antagonist IC83
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| NCI_Drug_Dictionary_ID | 536220
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| Legacy Concept Name | IC83
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 536220
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1881108
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