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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C67042
http://purl.obolibrary.org/obo/NCIT_C67042
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|---|---|
| Preferred Name | MDR Modulator CBT-1 |
| Definitions |
A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors. |
|---|---|
| prefLabel | MDR Modulator CBT-1
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| label | MDR Modulator CBT-1
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| PDQ_Closed_Trial_Search_ID | 538747
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| code | C67042
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| prefixIRI | NCIT:C67042
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| in_subset | |
| Preferred_Name | MDR Modulator CBT-1
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| Maps_To | MDR Modulator CBT-1
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| NCI_Drug_Dictionary_ID | 538747
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| Legacy Concept Name | CBT-1
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| type | |
| ALT_DEFINITION | A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 538747
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0916470
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