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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C67040
http://purl.obolibrary.org/obo/NCIT_C67040
|
|---|---|
| Preferred Name | Brivanib |
| Definitions |
A pyrrolotriazine-based compound and an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antineoplastic activity. BMS-540215 specifically targets and binds strongly to human VEGFR-2, a tyrosine kinase receptor and pro-angiogenic growth factor expressed almost exclusively on vascular endothelial cells. Blockade of VEGFR-2 by this agent may lead to an inhibition of VEGF-stimulated endothelial cell migration and proliferation, thereby inhibiting tumor angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pyrrolotriazine-based compound and an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antineoplastic activity. BMS-540215 specifically targets and binds strongly to human VEGFR-2, a tyrosine kinase receptor and pro-angiogenic growth factor expressed almost exclusively on vascular endothelial cells. Blockade of VEGFR-2 by this agent may lead to an inhibition of VEGF-stimulated endothelial cell migration and proliferation, thereby inhibiting tumor angiogenesis. |
|---|---|
| prefLabel | Brivanib
|
| label | Brivanib
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| PDQ_Closed_Trial_Search_ID | 539377
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| code | C67040
|
| Has_Target | |
| prefixIRI | NCIT:C67040
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| in_subset | |
| Preferred_Name | Brivanib
|
| FDA_UNII_Code | DDU33B674I
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| Contributing_Source | FDA
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| Chemical_Formula | C19H19FN4O3
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| Maps_To | Brivanib
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| CAS_Registry | 649735-46-6
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| NCI_Drug_Dictionary_ID | 539377
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| Legacy Concept Name | BMS-540215
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. Brivanib may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor 2 inhibitor and a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 539377
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2700604
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| Delete | Subject | Author | Type | Created |
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