Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C67039
http://purl.obolibrary.org/obo/NCIT_C67039
Preferred Name

Lutetium Lu-177 Capromab
Definitions
A radioimmunoconjugate consisting of capromab linked to lutetium Lu 177 via the bifunctional macrocyclic chelator methoxy-tetraazacyclododecane-tetraacetic acid (MeO-DOTA) with potential antineoplastic activity. Lutetium Lu 177-capromab binds to human prostate specific membrane antigen (PSMA) expressed on tumor cell surfaces via its capromab moiety and, upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor cells. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A radioimmunoconjugate consisting of capromab linked to lutetium Lu 177 via the bifunctional macrocyclic chelator methoxy-tetraazacyclododecane-tetraacetic acid (MeO-DOTA) with potential antineoplastic activity. Lutetium Lu 177-capromab binds to human prostate specific membrane antigen (PSMA) expressed on tumor cell surfaces via its capromab moiety and, upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor cells. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells.
prefLabel
Lutetium Lu-177 Capromab
label
Lutetium Lu-177 Capromab
PDQ_Closed_Trial_Search_ID
539702
code
C67039
prefixIRI
NCIT:C67039
in_subset
Preferred_Name
Lutetium Lu-177 Capromab
Maps_To
Lutetium Lu-177 Capromab
NCI_Drug_Dictionary_ID
539702
Legacy Concept Name
Lutetium_Lu_177_Monoclonal_Antibody_7E11
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
539702
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C1881486
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