Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C66984
http://purl.obolibrary.org/obo/NCIT_C66984
Preferred Name

Daniquidone
Definitions
A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent.
prefLabel
Daniquidone
label
Daniquidone
PDQ_Closed_Trial_Search_ID
539029
code
C66984
Has_Target
prefixIRI
NCIT:C66984
in_subset
Display_Name
Daniquidone
Preferred_Name
Daniquidone
FDA_UNII_Code
E780TX33D2
Contributing_Source
CTRP
FDA
Chemical_Formula
C15H11N3O
Maps_To
Daniquidone
CAS_Registry
67199-66-0
NSC Number
320846
NCI_Drug_Dictionary_ID
539029
Legacy Concept Name
Daniquidone
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. It may kill cancer cells by causing damage to the DNA. Batracylin is a type of heterocyclic aryl amine.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
539029
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0053006
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