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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C66978
http://purl.obolibrary.org/obo/NCIT_C66978
|
|---|---|
| Preferred Name | Lutetium Lu-177 Girentuximab |
| Definitions |
A radioimmunoconjugate consisting of the chimeric monoclonal antibody cG250 linked to the low energy beta-emitting radioisotope Lutetium 177, via the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), with potential antineoplastic activity. The antibody moiety of lutetium Lu-177-DOTA-chimeric monoclonal antibody cG250 binds to renal cell carcinoma (RCC) cells expressing the RCC-associated antigen G250; a cytotoxic dose of beta radiation is selectively delivered to G250-expressing RCC cells upon internalization of the radioimmunoconjugate.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of the chimeric monoclonal antibody cG250 linked to the low energy beta-emitting radioisotope Lutetium 177, via the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), with potential antineoplastic activity. The antibody moiety of lutetium Lu-177-DOTA-chimeric monoclonal antibody cG250 binds to renal cell carcinoma (RCC) cells expressing the RCC-associated antigen G250; a cytotoxic dose of beta radiation is selectively delivered to G250-expressing RCC cells upon internalization of the radioimmunoconjugate. |
|---|---|
| prefLabel | Lutetium Lu-177 Girentuximab
|
| label | Lutetium Lu-177 Girentuximab
|
| PDQ_Closed_Trial_Search_ID | 531051
|
| code | C66978
|
| prefixIRI | NCIT:C66978
|
| in_subset | |
| Preferred_Name | Lutetium Lu-177 Girentuximab
|
| Maps_To | Lutetium Lu-177 Girentuximab
|
| NCI_Drug_Dictionary_ID | 531051
|
| Legacy Concept Name | Lutetium_Lu_177-DOTA-Chimeric_Monoclonal_Antibody_cG250
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 531051
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1881485
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