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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C66961
http://purl.obolibrary.org/obo/NCIT_C66961
|
|---|---|
| Preferred Name | Checkpoint Kinase Inhibitor AZD7762 |
| Definitions |
A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication. |
|---|---|
| prefLabel | Checkpoint Kinase Inhibitor AZD7762
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| label | Checkpoint Kinase Inhibitor AZD7762
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| PDQ_Closed_Trial_Search_ID | 530784
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| code | C66961
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| Has_Target | |
| prefixIRI | NCIT:C66961
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| in_subset |
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| Display_Name | Checkpoint Kinase Inhibitor AZD7762
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| Preferred_Name | Checkpoint Kinase Inhibitor AZD7762
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| FDA_UNII_Code | 5D822Y3L1H
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Checkpoint Kinase Inhibitor AZD7762
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| CAS_Registry | 860352-01-8
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| NCI_Drug_Dictionary_ID | 530784
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| Legacy Concept Name | AZD7762
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 530784
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1832037
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| Delete | Subject | Author | Type | Created |
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