Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C66947
http://purl.obolibrary.org/obo/NCIT_C66947
Preferred Name

Multikinase Inhibitor AT9283
Definitions
A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs.
prefLabel
Multikinase Inhibitor AT9283
label
Multikinase Inhibitor AT9283
PDQ_Closed_Trial_Search_ID
534287
code
C66947
Has_Target
prefixIRI
NCIT:C66947
in_subset
Display_Name
Multikinase Inhibitor AT9283
Preferred_Name
Multikinase Inhibitor AT9283
FDA_UNII_Code
XAV9KYN9WL
Contributing_Source
CTRP
FDA
Maps_To
Multikinase Inhibitor AT9283
CAS_Registry
896466-04-9
NCI_Drug_Dictionary_ID
534287
Legacy Concept Name
AT9283
type
ALT_DEFINITION
A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
534287
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1879521
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