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Biological and Environmental Research Ontology
| Preferred Name | Brentuximab Vedotin | |
| Synonyms |
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| Definitions |
An antibody-drug conjugate (ADC) directed against the tumor necrosis factor (TNF) receptor CD30 with potential antineoplastic activity. Brentuximab vedotin is generated by conjugating the chimeric anti-CD30 monoclonal antibody SGN-30 to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline peptide linker. Upon administration and internalization by CD30-positive tumor cells, brentuximab vedotin undergoes enzymatic cleavage, releasing MMAE into the cytosol; MMAE binds to tubulin and inhibits tubulin polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. Transiently activated during lymphocyte activation, CD30 (tumor necrosis factor receptor superfamily, member 8;TNFRSF8) may be constitutively expressed in hematologic malignancies including Hodgkin lymphoma and some T-cell non-Hodgkin lymphomas. The linkage system in brentuximab vedotin is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive cells. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C66944 |
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| Accepted_Therapeutic_Use_For |
Hodgkin lymphoma (HL); anaplastic large cell lymphoma (ALCL); other CD30-expressing peripheral T-cell lymphomas
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| CAS_Registry |
914088-09-8
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| Chemical_Formula |
C68H106N11O15S
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| code |
C66944
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| Contributing_Source |
CTRP FDA PCDC
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| definition |
An antibody-drug conjugate (ADC) directed against the tumor necrosis factor (TNF) receptor CD30 with potential antineoplastic activity. Brentuximab vedotin is generated by conjugating the chimeric anti-CD30 monoclonal antibody SGN-30 to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline peptide linker. Upon administration and internalization by CD30-positive tumor cells, brentuximab vedotin undergoes enzymatic cleavage, releasing MMAE into the cytosol; MMAE binds to tubulin and inhibits tubulin polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. Transiently activated during lymphocyte activation, CD30 (tumor necrosis factor receptor superfamily, member 8;TNFRSF8) may be constitutively expressed in hematologic malignancies including Hodgkin lymphoma and some T-cell non-Hodgkin lymphomas. The linkage system in brentuximab vedotin is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive cells.
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| Display_Name |
Brentuximab Vedotin
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| FDA_UNII_Code |
7XL5ISS668
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 |
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| Is_Value_For_GDC_Property | ||
| label |
Brentuximab Vedotin
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| Legacy Concept Name |
SGN-35
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|
| Maps_To |
Brentuximab Vedotin
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| NCI_Drug_Dictionary_ID |
530758
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| PDQ_Closed_Trial_Search_ID |
530758
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| PDQ_Open_Trial_Search_ID |
530758
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| Preferred_Name |
Brentuximab Vedotin
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| prefixIRI |
NCIT:C66944
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| prefLabel |
Brentuximab Vedotin
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C2932409
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| subClassOf |
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