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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C66722
http://purl.obolibrary.org/obo/NCIT_C66722
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|---|---|
| Preferred Name | Oblimersen Sodium |
| Definitions |
The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance. |
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| prefLabel | Oblimersen Sodium
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| label | Oblimersen Sodium
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| PDQ_Closed_Trial_Search_ID | 42935
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| code | C66722
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| prefixIRI | NCIT:C66722
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| in_subset |
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| Display_Name | Oblimersen Sodium
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| Preferred_Name | Oblimersen Sodium
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| FDA_UNII_Code | SH55B0RQ9K
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C172H204N62O91P17S17.17Na
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| Maps_To | Oblimersen Sodium
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| CAS_Registry | 190977-41-4
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| NSC Number | 683428
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| NCI_Drug_Dictionary_ID | 42935
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| Legacy Concept Name | Oblimersen_Sodium
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42935
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0935954
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