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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C665
http://purl.obolibrary.org/obo/NCIT_C665
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|---|---|
| Preferred Name | Mitoxantrone Hydrochloride |
| Definitions |
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. |
|---|---|
| prefLabel | Mitoxantrone Hydrochloride
|
| label | Mitoxantrone Hydrochloride
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| CHEBI_ID | CHEBI:50727
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| PDQ_Closed_Trial_Search_ID | 39219
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| code | C665
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| Has_Target | |
| prefixIRI | NCIT:C665
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| in_subset |
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| Display_Name | Mitoxantrone Hydrochloride
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| Preferred_Name | Mitoxantrone Hydrochloride
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| FDA_UNII_Code | U6USW86RD0
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C22H28N4O6.2HCl
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| Maps_To | Mitoxantrone Hydrochloride
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| CAS_Registry | 70476-82-3
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| NSC Number | 301739
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| NCI_Drug_Dictionary_ID | 39219
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| Legacy Concept Name | Mitoxantrone
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39219
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| Accepted_Therapeutic_Use_For | Acute Leukemia; Breast cancer; Non Hodgkins Lymphoma; Multiple sclerosis; Prostate cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0700458
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