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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C664
http://purl.obolibrary.org/obo/NCIT_C664
|
|---|---|
| Preferred Name | Mitotane |
| Definitions |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04) |
|---|---|
| prefLabel | Mitotane
|
| label | Mitotane
|
| PDQ_Closed_Trial_Search_ID | 39506
|
| code | C664
|
| prefixIRI | NCIT:C664
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| in_subset |
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| Display_Name | Mitotane
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| Preferred_Name | Mitotane
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| FDA_UNII_Code | 78E4J5IB5J
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C14H10Cl4
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| Maps_To | Mitotane
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| CAS_Registry | 53-19-0
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| NSC Number | 38721
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| NCI_Drug_Dictionary_ID | 39506
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| Legacy Concept Name | Mitotane
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| type | |
| ALT_DEFINITION | An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39506
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| Accepted_Therapeutic_Use_For | Adrenocortical carcinoma
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0026256
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