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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C663
http://purl.obolibrary.org/obo/NCIT_C663
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|---|---|
| Preferred Name | Mitomycin Antineoplastic Antibiotic |
| Definitions |
Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis. |
|---|---|
| prefLabel | Mitomycin Antineoplastic Antibiotic
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| label | Mitomycin Antineoplastic Antibiotic
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| CHEBI_ID | CHEBI:25357
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| code | C663
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| prefixIRI | NCIT:C663
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| Preferred_Name | Mitomycin Antineoplastic Antibiotic
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| Legacy Concept Name | Mitomycin_Antibiotic
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
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| subClassOf | |
| Accepted_Therapeutic_Use_For | Anal cancer; Bladder cancer; Breast cancer; Bronchogenic cancer; Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric carcinoma; Head and neck cancer; Liver cancer; Pancreatic carcinoma; Pterygia
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| Semantic_Type | Chemical Viewed Functionally
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| UMLS_CUI | C0026254
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