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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C66215
http://purl.obolibrary.org/obo/NCIT_C66215
|
|---|---|
| Preferred Name | Mycophenolate Sodium |
| Definitions |
The sodium salt form of mycophenolic acid (MPA), with immunosuppressing activity. In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase (IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation of B and T lymphocytes. Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt form of mycophenolic acid (MPA), with immunosuppressing activity. In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase (IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation of B and T lymphocytes. Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity. |
|---|---|
| prefLabel | Mycophenolate Sodium
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| label | Mycophenolate Sodium
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| code | C66215
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| prefixIRI | NCIT:C66215
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| in_subset | |
| Preferred_Name | Mycophenolate Sodium
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| FDA_UNII_Code | WX877SQI1G
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| Contributing_Source | FDA
|
| Chemical_Formula | C17H19O6.Na
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| CAS_Registry | 37415-62-6
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| NSC Number | 116072
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| Legacy Concept Name | Mycophenolate_Sodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1337395
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