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Biological and Environmental Research Ontology
Acronym | BERO |
Visibility | Public |
Description | Biological and Environmental Research Ontology (BERO) is an application ontology developed by the combination of many ontologies (base or subsets) namely : ChEBI, ECOCORE, EDAM, ENVO, GO, MeSH, MOP, NCBITaxon, NCIT, OBI, OMO, PATO, PO and TO. |
Status | Alpha |
Format | OWL |
Contact | Chris Mungall, cjmungall@lbl.gov Nicolas Matentzoglu, nicolas.matentzoglu@gmail.com Harshad Hegde, hhegde@lbl.gov |
No views of BERO available
Id | http://purl.obolibrary.org/obo/NCIT_C66189
http://purl.obolibrary.org/obo/NCIT_C66189
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Preferred Name | Montelukast |
Definitions |
A selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating activities. Upon administration, montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events including migration of eosinophils and neutrophils, adhesion of leukocytes to vascular endothelium, monocyte and neutrophil aggregation, increased airway edema, increased capillary permeability, and bronchoconstriction. The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells.
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating activities. Upon administration, montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events including migration of eosinophils and neutrophils, adhesion of leukocytes to vascular endothelium, monocyte and neutrophil aggregation, increased airway edema, increased capillary permeability, and bronchoconstriction. The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells. |
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label |
Montelukast
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prefLabel |
Montelukast
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Legacy Concept Name |
Montelukast
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in_subset | |
Preferred_Name |
Montelukast
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Chemical_Formula |
C35H36ClNO3S
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Display_Name |
Montelukast
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UMLS_CUI |
C0298130
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FDA_UNII_Code |
MHM278SD3E
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prefixIRI |
NCIT:C66189
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Contributing_Source |
CTRP
FDA
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subClassOf | |
CHEBI_ID |
CHEBI:50730
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Has_Salt_Form | |
code |
C66189
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type | |
ALT_DEFINITION |
The active ingredient in a drug used to treat symptoms of asthma, such as trouble breathing, tight chest, wheezing, coughing, and runny nose. Montelukast blocks the action of a substance that causes airways in the lungs to narrow and causes other symptoms of asthma. It is a type of leukotriene receptor antagonist and a type of antiasthmatic agent.
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Semantic_Type |
Pharmacologic Substance
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CAS_Registry |
158966-92-8
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- Problem retrieving properties:
Notes
Add NCBO Web Widgets to your site for BERO
Widget type | Widget demonstration |
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Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
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Example 1 (start typing the class name to get its full URI)
Example 2 (get the ID for a class) Example 3 (get the preferred name for a class) Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
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Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=BERO&class=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FMOP_0000634&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki |
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Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <link rel="stylesheet" type="text/css" href="/widgets/jquery.ncbo.tree.css"> <script src="/widgets/jquery.ncbo.tree-2.0.2.js"></script> <div id="widget_tree"></div> var widget_tree = $("#widget_tree").NCBOTree({ apikey: "YOUR_API_KEY", ontology: "BERO" }); You can also view a detailed demonstration For more help visit NCBO Widget Wiki |