Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Id | http://purl.obolibrary.org/obo/NCIT_C66181
http://purl.obolibrary.org/obo/NCIT_C66181
|
|---|---|
| Preferred Name | Mometasone |
| Definitions |
A synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2. |
|---|---|
| label | Mometasone
|
| prefLabel | Mometasone
|
| Legacy Concept Name | Mometasone
|
| in_subset | |
| Preferred_Name | Mometasone
|
| Chemical_Formula | C22H28Cl2O4
|
| UMLS_CUI | C0360564
|
| FDA_UNII_Code | 8HR4QJ6DW8
|
| prefixIRI | NCIT:C66181
|
| Contributing_Source | FDA
|
| subClassOf | |
| CHEBI_ID | CHEBI:6970
|
| Has_Salt_Form | |
| code | C66181
|
| type | |
| ALT_DEFINITION | A drug that is used in a cream to treat certain skin conditions and in a nasal spray to treat sinus problems caused by allergies. It is being studied as a way to treat inflammation of the skin caused by radiation therapy. Mometasone is a type of corticosteroid.
|
| Semantic_Type | Pharmacologic Substance
|
| CAS_Registry | 105102-22-5
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |