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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C661
http://purl.obolibrary.org/obo/NCIT_C661
|
|---|---|
| Preferred Name | Mitoguazone |
| Definitions |
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04) |
|---|---|
| prefLabel | Mitoguazone
|
| label | Mitoguazone
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39500
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| code | C661
|
| prefixIRI | NCIT:C661
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| in_subset | |
| Preferred_Name | Mitoguazone
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| FDA_UNII_Code | OD5Q0L447W
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| Contributing_Source | FDA
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| Chemical_Formula | C5H12N8
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| Maps_To | Mitoguazone
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| CAS_Registry | 459-86-9
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| NSC Number | 32946
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| NCI_Drug_Dictionary_ID | 39500
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| Legacy Concept Name | Mitoguazone
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39500
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0026251
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| Delete | Subject | Author | Type | Created |
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