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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C658
http://purl.obolibrary.org/obo/NCIT_C658
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|---|---|
| Preferred Name | Plicamycin |
| Definitions |
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04) |
|---|---|
| prefLabel | Plicamycin
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| label | Plicamycin
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| CHEBI_ID | CHEBI:31856
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| PDQ_Closed_Trial_Search_ID | 41738
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| code | C658
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| Has_Target | |
| prefixIRI | NCIT:C658
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| in_subset |
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| Display_Name | Plicamycin
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| Preferred_Name | Plicamycin
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| FDA_UNII_Code | NIJ123W41V
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C52H76O24
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| Maps_To | Plicamycin
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| CAS_Registry | 18378-89-7
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| NSC Number | 24559
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| NCI_Drug_Dictionary_ID | 41738
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| Legacy Concept Name | Plicamycin
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| type | |
| ALT_DEFINITION | A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41738
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0026234
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