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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C657
http://purl.obolibrary.org/obo/NCIT_C657
|
|---|---|
| Preferred Name | Misonidazole |
| Definitions |
A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04) |
|---|---|
| prefLabel | Misonidazole
|
| label | Misonidazole
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| PDQ_Closed_Trial_Search_ID | 39504
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| code | C657
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| prefixIRI | NCIT:C657
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| in_subset | |
| Preferred_Name | Misonidazole
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| FDA_UNII_Code | 8FE7LTN8XE
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| Contributing_Source | FDA
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| Chemical_Formula | C7H11N3O4
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| Maps_To | Misonidazole
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| CAS_Registry | 13551-87-6
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| NSC Number | 261037
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| NCI_Drug_Dictionary_ID | 39504
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| Legacy Concept Name | Misonidazole
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39504
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0026218
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