loading...| Preferred Name | Darunavir | |
| Synonyms |
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|
| Definitions |
A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C65364 |
|
| CAS_Registry |
206361-99-1 |
|
| CHEBI_ID |
CHEBI:367163 |
|
| Chemical_Formula |
C27H37N3O7S |
|
| code |
C65364 |
|
| Contributing_Source |
FDA |
|
| definition |
A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication. |
|
| FDA_UNII_Code |
YO603Y8113 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Darunavir |
|
| Legacy Concept Name |
Darunavir |
|
| Preferred_Name |
Darunavir |
|
| prefixIRI |
NCIT:C65364 |
|
| prefLabel |
Darunavir |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1435444 |
|
| subClassOf |