Preferred Name | Clioquinol | |
Synonyms |
|
|
Definitions |
An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C65337 |
|
CAS_Registry |
130-26-7 |
|
Chemical_Formula |
C9H5ClINO |
|
code |
C65337 |
|
Contributing_Source |
FDA |
|
definition |
An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors. |
|
FDA_UNII_Code |
7BHQ856EJ5 |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
Is_Value_For_GDC_Property | ||
label |
Clioquinol |
|
Legacy Concept Name |
Clioquinol |
|
Maps_To |
Clioquinol |
|
NCI_Drug_Dictionary_ID |
653982 |
|
NSC Number |
3531 |
|
PDQ_Closed_Trial_Search_ID |
653982 |
|
PDQ_Open_Trial_Search_ID |
653982 |
|
Preferred_Name |
Clioquinol |
|
prefixIRI |
NCIT:C65337 |
|
prefLabel |
Clioquinol |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0021978 |
|
subClassOf |