Link to this page
Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C64781
http://purl.obolibrary.org/obo/NCIT_C64781
|
|---|---|
| Preferred Name | Apoptosis Inducer MPC-2130 |
| Definitions |
A broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine externalization, release of cytochrome C from mitochondria, caspase activation, cell condensation, and DNA fragmentation. In addition, because this agent is not a substrate for several types of multidrug resistance (MDR) ABC superfamily transporters, such as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR tumors that express these particular MDR efflux pumps.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine externalization, release of cytochrome C from mitochondria, caspase activation, cell condensation, and DNA fragmentation. In addition, because this agent is not a substrate for several types of multidrug resistance (MDR) ABC superfamily transporters, such as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR tumors that express these particular MDR efflux pumps. |
|---|---|
| prefLabel | Apoptosis Inducer MPC-2130
|
| label | Apoptosis Inducer MPC-2130
|
| PDQ_Closed_Trial_Search_ID | 526178
|
| code | C64781
|
| prefixIRI | NCIT:C64781
|
| in_subset | |
| Preferred_Name | Apoptosis Inducer MPC-2130
|
| Maps_To | Apoptosis Inducer MPC-2130
|
| NCI_Drug_Dictionary_ID | 526178
|
| Legacy Concept Name | MPC-2130
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 526178
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C1881499
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |