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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Methylprednisolone | |
| Synonyms |
|
|
| Definitions |
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C647 |
|
| Accepted_Therapeutic_Use_For |
Adrenocortical insufficiency; Conditions requiring immunosuppression; Inflammatory conditions; Multiple Sclerosis; Nephrotic syndrome
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| ALT_DEFINITION |
A corticosteroid hormone replacement.
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|
| CAS_Registry |
83-43-2
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| CHEBI_ID |
CHEBI:6888
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| Chemical_Formula |
C22H30O5
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|
| code |
C647
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
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|
| Display_Name |
Methylprednisolone
|
|
| FDA_UNII_Code |
X4W7ZR7023
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Methylprednisolone
|
|
| Legacy Concept Name |
Methylprednisolone
|
|
| Maps_To |
Methylprednisolone
|
|
| NCI_Drug_Dictionary_ID |
41528
|
|
| NSC Number |
19987
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|
| PDQ_Closed_Trial_Search_ID |
41528
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|
| PDQ_Open_Trial_Search_ID |
41528
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|
| Preferred_Name |
Methylprednisolone
|
|
| prefixIRI |
NCIT:C647
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|
| prefLabel |
Methylprednisolone
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0025815
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|
| subClassOf |
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