Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C647
http://purl.obolibrary.org/obo/NCIT_C647
Preferred Name

Methylprednisolone
Definitions
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
prefLabel
Methylprednisolone
label
Methylprednisolone
CHEBI_ID
CHEBI:6888
PDQ_Closed_Trial_Search_ID
41528
code
C647
Has_Target
prefixIRI
NCIT:C647
in_subset
Display_Name
Methylprednisolone
Preferred_Name
Methylprednisolone
FDA_UNII_Code
X4W7ZR7023
Contributing_Source
CTRP
FDA
Chemical_Formula
C22H30O5
Maps_To
Methylprednisolone
CAS_Registry
83-43-2
NSC Number
19987
NCI_Drug_Dictionary_ID
41528
Legacy Concept Name
Methylprednisolone
type
ALT_DEFINITION
A corticosteroid hormone replacement.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41528
Accepted_Therapeutic_Use_For
Adrenocortical insufficiency; Conditions requiring immunosuppression; Inflammatory conditions; Multiple Sclerosis; Nephrotic syndrome
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0025815
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