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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C64540
http://purl.obolibrary.org/obo/NCIT_C64540
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|---|---|
| Preferred Name | Cenisertib |
| Definitions |
A water-soluble, synthetic small molecule with potential antineoplastic activity. Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer. Inhibition of aurora kinases inhibits cell division and proliferation and induces apoptosis in tumor cells overexpressing AKs.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A water-soluble, synthetic small molecule with potential antineoplastic activity. Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer. Inhibition of aurora kinases inhibits cell division and proliferation and induces apoptosis in tumor cells overexpressing AKs. |
|---|---|
| prefLabel | Cenisertib
|
| label | Cenisertib
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| PDQ_Closed_Trial_Search_ID | 522734
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| code | C64540
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| Has_Target | |
| prefixIRI | NCIT:C64540
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| in_subset |
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| Display_Name | Cenisertib
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| Preferred_Name | Cenisertib
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| FDA_UNII_Code | 5277GPA358
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C24H30FN7O
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| Maps_To | Cenisertib
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| CAS_Registry | 871357-89-0
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| NCI_Drug_Dictionary_ID | 522734
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| Legacy Concept Name | R763
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 522734
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3853900
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