Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C643
http://purl.obolibrary.org/obo/NCIT_C643
Preferred Name

Methoxsalen
Definitions
A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)
prefLabel
Methoxsalen
label
Methoxsalen
CHEBI_ID
CHEBI:18358
PDQ_Closed_Trial_Search_ID
39499
code
C643
prefixIRI
NCIT:C643
in_subset
Display_Name
Methoxsalen
Preferred_Name
Methoxsalen
FDA_UNII_Code
U4VJ29L7BQ
Contributing_Source
CTRP
FDA
Chemical_Formula
C12H8O4
Maps_To
Methoxsalen
CAS_Registry
298-81-7
NSC Number
45923
NCI_Drug_Dictionary_ID
39499
Legacy Concept Name
Methoxsalen
type
ALT_DEFINITION
A drug used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. It is also being studied in the treatment of graft-versus-host disease. It belongs to the family of drugs called psoralens and furocoumarins.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39499
Accepted_Therapeutic_Use_For
Cutaneous T-cell lymphoma; psoriasis; vitiligo
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0025684
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