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Biological and Environmental Research Ontology
| Preferred Name | Asparaginase Erwinia chrysanthemi | |
| Synonyms |
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| Definitions |
An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C64260 |
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| Accepted_Therapeutic_Use_For |
Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
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| CAS_Registry |
9015-68-3
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| code |
C64260
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| Contributing_Source |
CTRP FDA
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| definition |
An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation.
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| Display_Name |
Asparaginase Erwinia chrysanthemi
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| FDA_UNII_Code |
D733ET3F9O
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Asparaginase Erwinia chrysanthemi
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| Legacy Concept Name |
Asparaginase-Erwinia
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| Maps_To |
Asparaginase Erwinia chrysanthemi
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| NCI_Drug_Dictionary_ID |
601044
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| NSC Number |
106977
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| PDQ_Closed_Trial_Search_ID |
601044
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| PDQ_Open_Trial_Search_ID |
601044
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| Preferred_Name |
Asparaginase Erwinia chrysanthemi
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| prefixIRI |
NCIT:C64260
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| prefLabel |
Asparaginase Erwinia chrysanthemi
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| Semantic_Type |
Pharmacologic Substance Enzyme
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| UMLS_CUI |
C0771210
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| subClassOf |
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