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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C642
http://purl.obolibrary.org/obo/NCIT_C642
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|---|---|
| Preferred Name | Methotrexate |
| Definitions |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. |
|---|---|
| prefLabel | Methotrexate
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| label | Methotrexate
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:44185
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| PDQ_Closed_Trial_Search_ID | 41719
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| code | C642
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| Has_Target | |
| prefixIRI | NCIT:C642
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| in_subset |
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| Display_Name | Methotrexate
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| Preferred_Name | Methotrexate
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| FDA_UNII_Code | YL5FZ2Y5U1
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| Is_PCDC_AML_Permissible_Value_For_Variable | |
| Contributing_Source |
CTRP
FDA
GDC
PCDC
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| Chemical_Formula | C20H22N8O5
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| Maps_To | Methotrexate
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| CAS_Registry | 59-05-2
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| NSC Number | 740
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| NCI_Drug_Dictionary_ID | 41719
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| Legacy Concept Name | Methotrexate
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| type | |
| ALT_DEFINITION | A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41719
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| Accepted_Therapeutic_Use_For | Graft versus host disease-prophylaxis; Head/neck cancer; Hydatidiform mole; Leukemia; meningeal; Lymphomas; Acute Lymphoblastic Leukemia; Burkitt's; Lung cancer; Mycosis fungoides; Osteosarcoma; Psoriasis; Rheumatoid arthritis; Wegener's granulomatosis
Abortion; Bladder cancer; Breast cancer; Carcinomatous; meningitis; Chorioadenoma destruens; Crohn's disease; Ectopic pregnancy; Esophageal cancer; Gestational choriocarcinoma
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0025677
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