Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Id | http://purl.obolibrary.org/obo/NCIT_C641
http://purl.obolibrary.org/obo/NCIT_C641
|
|---|---|
| Preferred Name | Methimazole |
| Definitions |
A thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). |
|---|---|
| label |
Methimazole
|
| prefLabel |
Methimazole
|
| Legacy Concept Name |
Methimazole
|
| in_subset | |
| Preferred_Name |
Methimazole
|
| Chemical_Formula |
C4H6N2S
|
| Display_Name |
Methimazole
|
| PDQ_Open_Trial_Search_ID |
39287
|
| Has_Target | |
| UMLS_CUI |
C0025644
|
| FDA_UNII_Code |
554Z48XN5E
|
| prefixIRI |
NCIT:C641
|
| NCI_Drug_Dictionary_ID |
39287
|
| Contributing_Source |
CTRP
FDA
|
| subClassOf | |
| CHEBI_ID |
CHEBI:50673
|
| code |
C641
|
| type | |
| NSC Number |
38608
|
| PDQ_Closed_Trial_Search_ID |
39287
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry |
60-56-0
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |