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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C63546
http://purl.obolibrary.org/obo/NCIT_C63546
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|---|---|
| Preferred Name | Fresolimumab |
| Definitions |
A pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity. Fresolimumab binds to and inhibits the activity of all isoforms of TGF-beta, which may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity. Fresolimumab binds to and inhibits the activity of all isoforms of TGF-beta, which may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells. |
|---|---|
| prefLabel | Fresolimumab
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| label | Fresolimumab
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| PDQ_Closed_Trial_Search_ID | 530302
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| code | C63546
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| Has_Target | |
| prefixIRI | NCIT:C63546
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| in_subset |
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| Display_Name | Fresolimumab
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| Preferred_Name | Fresolimumab
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| FDA_UNII_Code | 375142VBIA
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Fresolimumab
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| CAS_Registry | 948564-73-6
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| NCI_Drug_Dictionary_ID | 530302
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| Legacy Concept Name | Anti-TGF-Beta_Monoclonal_Antibody_GC1008
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| type | |
| ALT_DEFINITION | A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-TGF-beta monoclonal antibody GC1008 binds to the protein transforming growth factor-beta (TGF?) and may block the growth of cancer cells that make it.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 530302
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| Accepted_Therapeutic_Use_For | Idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, and cancer
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C2987643
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