Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C633
http://purl.obolibrary.org/obo/NCIT_C633
Preferred Name

Melphalan
Definitions
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
prefLabel
Melphalan
label
Melphalan
Has_Salt_Form
CHEBI_ID
CHEBI:28876
PDQ_Closed_Trial_Search_ID
779085
code
C633
prefixIRI
NCIT:C633
in_subset
Display_Name
Melphalan
Preferred_Name
Melphalan
FDA_UNII_Code
Q41OR9510P
Is_PCDC_AML_Permissible_Value_For_Variable
Contributing_Source
CTRP
FDA
PCDC
Chemical_Formula
C13H18Cl2N2O2
Maps_To
Melphalan
CAS_Registry
148-82-3
NSC Number
241286
8806
NCI_Drug_Dictionary_ID
779085
Legacy Concept Name
Melphalan
Is_PCDC_GCT_Permissible_Value_For_Variable
type
ALT_DEFINITION
A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
779085
Accepted_Therapeutic_Use_For
Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C0025241
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