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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C629
http://purl.obolibrary.org/obo/NCIT_C629
|
|---|---|
| Preferred Name | Medroxyprogesterone |
| Definitions |
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04) |
|---|---|
| prefLabel | Medroxyprogesterone
|
| label | Medroxyprogesterone
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| CHEBI_ID | CHEBI:6715
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| PDQ_Closed_Trial_Search_ID | 39813
|
| code | C629
|
| Has_Target | |
| prefixIRI | NCIT:C629
|
| in_subset |
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| Display_Name | Medroxyprogesterone
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| Preferred_Name | Medroxyprogesterone
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| FDA_UNII_Code | HSU1C9YRES
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C22H32O3
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| Maps_To | Medroxyprogesterone
|
| CAS_Registry | 520-85-4
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| NSC Number | 27408
|
| NCI_Drug_Dictionary_ID | 39813
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| Legacy Concept Name | Medroxyprogesterone
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| type | |
| ALT_DEFINITION | A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39813
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| Accepted_Therapeutic_Use_For | Breast carcinoma; Contraception; Endometrial carcinoma; Renal cell carcinoma
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0025147
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| Delete | Subject | Author | Type | Created |
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