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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62794
http://purl.obolibrary.org/obo/NCIT_C62794
|
|---|---|
| Preferred Name | Tasisulam |
| Definitions |
An acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity. |
|---|---|
| prefLabel | Tasisulam
|
| label | Tasisulam
|
| code | C62794
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| prefixIRI | NCIT:C62794
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| in_subset | |
| Preferred_Name | Tasisulam
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| FDA_UNII_Code | 1YC4W9MSLJ
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| Contributing_Source | FDA
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| Chemical_Formula | C11H6BrCl2NO3S2
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| Maps_To | Tasisulam
|
| CAS_Registry | 519055-62-0
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| Legacy Concept Name | LY573636
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831958
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