Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C62763
http://purl.obolibrary.org/obo/NCIT_C62763
Preferred Name

Synthetic Alkaloid PM00104
Definitions
A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential antineoplastic activity. PM00104 reversibly binds to DNA, thereby inducing cytotoxicity due to its interference with DNA replication, transcription, and translation processes. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 demonstrates a manageable and reversible cytotoxicity as part of its antitumor activity.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential antineoplastic activity. PM00104 reversibly binds to DNA, thereby inducing cytotoxicity due to its interference with DNA replication, transcription, and translation processes. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 demonstrates a manageable and reversible cytotoxicity as part of its antitumor activity.
prefLabel
Synthetic Alkaloid PM00104
label
Synthetic Alkaloid PM00104
PDQ_Closed_Trial_Search_ID
502184
code
C62763
Has_Target
prefixIRI
NCIT:C62763
in_subset
Display_Name
PM00104
Preferred_Name
Synthetic Alkaloid PM00104
FDA_UNII_Code
C21EZR41AY
Contributing_Source
CTRP
FDA
Maps_To
Synthetic Alkaloid PM00104
CAS_Registry
308359-57-1
NCI_Drug_Dictionary_ID
502184
Legacy Concept Name
PM00104
PubMedID_Primary_Reference
19584237
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
502184
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1568937
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