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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62639
http://purl.obolibrary.org/obo/NCIT_C62639
|
|---|---|
| Preferred Name | BMS-275183 |
| Definitions |
An orally available, C-4 methyl carbonate analog of paclitaxel with potential antineoplastic activity. Like paclitaxel, BMS-275183 binds to tubulin and stabilizes microtubules, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and an induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, C-4 methyl carbonate analog of paclitaxel with potential antineoplastic activity. Like paclitaxel, BMS-275183 binds to tubulin and stabilizes microtubules, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and an induction of apoptosis. |
|---|---|
| label | BMS-275183
|
| prefLabel | BMS-275183
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| Legacy Concept Name | BMS-275183
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| in_subset | |
| Preferred_Name | BMS-275183
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| Is_Value_For_GDC_Property | |
| Maps_To | BMS-275183
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| PDQ_Open_Trial_Search_ID | 415311
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| UMLS_CUI | C1098058
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| FDA_UNII_Code | UQC681JJIV
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| prefixIRI | NCIT:C62639
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| NCI_Drug_Dictionary_ID | 415311
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| Contributing_Source | FDA
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| subClassOf | |
| code | C62639
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| type | |
| PDQ_Closed_Trial_Search_ID | 415311
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 355113-98-3
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