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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C626
http://purl.obolibrary.org/obo/NCIT_C626
|
|---|---|
| Preferred Name | Maytansine |
| Definitions |
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04) |
|---|---|
| prefLabel | Maytansine
|
| label | Maytansine
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| PDQ_Closed_Trial_Search_ID | 39492
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| code | C626
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| prefixIRI | NCIT:C626
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| in_subset | |
| Preferred_Name | Maytansine
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| FDA_UNII_Code | 14083FR882
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| Contributing_Source | FDA
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| Chemical_Formula | C34H46ClN3O10
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| Maps_To | Maytansine
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| CAS_Registry | 35846-53-8
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| NSC Number | 153858
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| NCI_Drug_Dictionary_ID | 39492
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| Legacy Concept Name | Maytansine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39492
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0024975
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