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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62554
http://purl.obolibrary.org/obo/NCIT_C62554
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|---|---|
| Preferred Name | Poly (ADP-Ribose) Polymerase Inhibitor |
| Definitions |
Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death. |
|---|---|
| prefLabel | Poly (ADP-Ribose) Polymerase Inhibitor
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| label | Poly (ADP-Ribose) Polymerase Inhibitor
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| CHEBI_ID | CHEBI:62913
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| code | C62554
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| prefixIRI | NCIT:C62554
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| in_subset | |
| Display_Name | PARP Inhibitor
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| Preferred_Name | Poly (ADP-Ribose) Polymerase Inhibitor
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| Contributing_Source | CTRP
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| Legacy Concept Name | Poly_ADP-Ribose_Polymerase_Inhibitor
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| type | |
| ALT_DEFINITION | A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. It may cause cancer cells to die. It is a type of targeted therapy.
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| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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| UMLS_CUI | C1882413
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