Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C62524
http://purl.obolibrary.org/obo/NCIT_C62524
Preferred Name

Seneca Valley Virus-001
Definitions
A replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization.
prefLabel
Seneca Valley Virus-001
label
Seneca Valley Virus-001
NCI_META_CUI
CL365090
PDQ_Closed_Trial_Search_ID
488482
code
C62524
prefixIRI
NCIT:C62524
in_subset
Display_Name
Seneca Valley Virus-001
Preferred_Name
Seneca Valley Virus-001
Contributing_Source
CTRP
Maps_To
Seneca Valley Virus-001
NCI_Drug_Dictionary_ID
488482
Legacy Concept Name
Seneca_Valley_Virus
type
ALT_DEFINITION
A virus being studied in the treatment of neuroendocrine tumors and other types of cancer. Neuroendocrine tumors form from cells that release hormones in response to a signal from the nervous system. The virus infects and breaks down these tumor cells but not normal cells. It is a type of oncolytic virus.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
488482
Semantic_Type
Pharmacologic Substance
Virus
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