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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62523
http://purl.obolibrary.org/obo/NCIT_C62523
|
|---|---|
| Preferred Name | CDK Inhibitor SNS-032 |
| Definitions |
A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth. |
|---|---|
| prefLabel | CDK Inhibitor SNS-032
|
| label | CDK Inhibitor SNS-032
|
| PDQ_Closed_Trial_Search_ID | 488948
|
| code | C62523
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| Has_Target | |
| prefixIRI | NCIT:C62523
|
| in_subset | |
| Preferred_Name | CDK Inhibitor SNS-032
|
| FDA_UNII_Code | 9979I93686
|
| Contributing_Source | FDA
|
| Maps_To | CDK Inhibitor SNS-032
|
| CAS_Registry | 345627-80-7
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| NCI_Drug_Dictionary_ID | 488948
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| Legacy Concept Name | SNS-032
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 488948
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1451099
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