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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62522
http://purl.obolibrary.org/obo/NCIT_C62522
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|---|---|
| Preferred Name | AR Antagonist BMS-641988 |
| Definitions |
An androgen receptor (AR) antagonist with potential antineoplastic and anti-androgenic activities. BMS-641988 binds to the androgen receptor in target tissues, thereby preventing androgen-induced receptor activation, and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This may inhibit androgen-dependent gene expression, subsequently leading to an inhibition of cell growth and apoptosis in AR-expressing cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An androgen receptor (AR) antagonist with potential antineoplastic and anti-androgenic activities. BMS-641988 binds to the androgen receptor in target tissues, thereby preventing androgen-induced receptor activation, and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This may inhibit androgen-dependent gene expression, subsequently leading to an inhibition of cell growth and apoptosis in AR-expressing cells. |
|---|---|
| prefLabel | AR Antagonist BMS-641988
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| label | AR Antagonist BMS-641988
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| PDQ_Closed_Trial_Search_ID | 489385
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| code | C62522
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| Has_Target | |
| prefixIRI | NCIT:C62522
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| in_subset |
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| Display_Name | AR Antagonist BMS-641988
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| Preferred_Name | AR Antagonist BMS-641988
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| FDA_UNII_Code | W17M53Y8IM
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| Contributing_Source |
CTRP
FDA
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| Maps_To | AR Antagonist BMS-641988
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| CAS_Registry | 1093276-09-5
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| NCI_Drug_Dictionary_ID | 489385
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| Legacy Concept Name | BMS-641988
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 489385
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831892
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