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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62514
http://purl.obolibrary.org/obo/NCIT_C62514
|
|---|---|
| Preferred Name | Tiomolibdate Choline |
| Definitions |
An orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis. |
|---|---|
| prefLabel | Tiomolibdate Choline
|
| label | Tiomolibdate Choline
|
| PDQ_Closed_Trial_Search_ID | 500040
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| code | C62514
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| Has_Target | |
| prefixIRI | NCIT:C62514
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| in_subset | |
| Preferred_Name | Tiomolibdate Choline
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| FDA_UNII_Code | FD57A79R4P
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| Contributing_Source | FDA
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| Chemical_Formula | 2C5H14NO.MoS4
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| Maps_To |
Tiomolibdate Choline
Bis(choline)tetrathiomolybdate
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| CAS_Registry | 649749-10-0
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| NCI_Drug_Dictionary_ID | 500040
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| Legacy Concept Name | ATN-224
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes that cells need to divide and grow, and it may kill cancer cells. It is a type of antiangiogenesis agent and a type of superoxide dismutase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 500040
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831930
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