Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C62480
http://purl.obolibrary.org/obo/NCIT_C62480
Preferred Name

Immunotoxin CMD-193
Definitions
A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin, a hydrophobic enediyne antibiotic, with potential antineoplastic activity. CMD193 binds to the Lewis Y antigen, a tetrasaccharide expressed on the cell surfaces of many tumor cell types. Upon binding, CMD-193 is internalized, thereby delivering the attached calicheamicin to Lewis Y antigen-expressing tumor cells. Calicheamicin binds non-covalently to the minor groove of DNA and prompts conformational changes and DNA oxidation, thereby inhibiting DNA synthesis and inducing apoptosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin, a hydrophobic enediyne antibiotic, with potential antineoplastic activity. CMD193 binds to the Lewis Y antigen, a tetrasaccharide expressed on the cell surfaces of many tumor cell types. Upon binding, CMD-193 is internalized, thereby delivering the attached calicheamicin to Lewis Y antigen-expressing tumor cells. Calicheamicin binds non-covalently to the minor groove of DNA and prompts conformational changes and DNA oxidation, thereby inhibiting DNA synthesis and inducing apoptosis.
prefLabel
Immunotoxin CMD-193
label
Immunotoxin CMD-193
PDQ_Closed_Trial_Search_ID
489295
code
C62480
prefixIRI
NCIT:C62480
in_subset
Preferred_Name
Immunotoxin CMD-193
Maps_To
Immunotoxin CMD-193
CAS_Registry
1080645-97-1
NCI_Drug_Dictionary_ID
489295
Legacy Concept Name
CMD-193
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
489295
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C1879965
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