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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62178
http://purl.obolibrary.org/obo/NCIT_C62178
|
|---|---|
| Preferred Name | L-Gossypol |
| Definitions |
The levo-enantiomer of an orally bioavailable polyphenolic aldehyde, derived primarily from unrefined cottonseed oil, with potential antineoplastic activity. Mimicking the inhibitory BH3 (Bcl-2 homology 3) domain of endogenous antagonists of Bcl-2, L-gossypol binds to and inhibits various anti-apoptotic Bcl-2 proteins, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. This agent has greater affinity for Bcl-2 proteins than racemic gossypol.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The levo-enantiomer of an orally bioavailable polyphenolic aldehyde, derived primarily from unrefined cottonseed oil, with potential antineoplastic activity. Mimicking the inhibitory BH3 (Bcl-2 homology 3) domain of endogenous antagonists of Bcl-2, L-gossypol binds to and inhibits various anti-apoptotic Bcl-2 proteins, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. This agent has greater affinity for Bcl-2 proteins than racemic gossypol. |
|---|---|
| prefLabel | L-Gossypol
|
| label | L-Gossypol
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| PDQ_Closed_Trial_Search_ID | 570759
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| code | C62178
|
| prefixIRI | NCIT:C62178
|
| in_subset | |
| Preferred_Name | L-Gossypol
|
| Maps_To | L-Gossypol
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| CAS_Registry | 90141-22-3
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| NCI_Drug_Dictionary_ID | 570759
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| Legacy Concept Name | L-Gossypol
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 570759
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1831823
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