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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62056
http://purl.obolibrary.org/obo/NCIT_C62056
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|---|---|
| Preferred Name | Mechlorethamine |
| Definitions |
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) |
|---|---|
| prefLabel | Mechlorethamine
|
| label | Mechlorethamine
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:28925
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| code | C62056
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| prefixIRI | NCIT:C62056
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| in_subset |
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| Preferred_Name | Mechlorethamine
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| FDA_UNII_Code | 50D9XSG0VR
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| Contributing_Source |
CDISC
FDA
PCDC
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| Chemical_Formula | C5H11Cl2N
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| Maps_To | Mechlorethamine
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| CAS_Registry | 51-75-2
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| Legacy Concept Name | Mechlorethamine
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| type | |
| ALT_DEFINITION | The nitrogen mustard vesicant HN-2.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0025033
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