Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C62050
http://purl.obolibrary.org/obo/NCIT_C62050
Preferred Name

Mitoxantrone
Definitions
An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
label
Mitoxantrone
prefLabel
Mitoxantrone
Legacy Concept Name
Mitoxantrone_Base
in_subset
Preferred_Name
Mitoxantrone
Is_Value_For_GDC_Property
Chemical_Formula
C22H28N4O6
Display_Name
Mitoxantrone
Maps_To
Mitoxantrone
Has_Target
UMLS_CUI
C0026259
FDA_UNII_Code
BZ114NVM5P
prefixIRI
NCIT:C62050
Contributing_Source
CTRP
FDA
PCDC
subClassOf
CHEBI_ID
CHEBI:50729
Is_PCDC_AML_Permissible_Value_For_Variable
Has_Salt_Form
code
C62050
type
ALT_DEFINITION
A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.
NSC Number
279836
Semantic_Type
Organic Chemical
Pharmacologic Substance
CAS_Registry
65271-80-9
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